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Ling Cao, M.D., Ph.D.
Professor
      College of Osteopathic Medicine: Department of Biomedical Sciences
Center for Excellence in the Neurosciences
College of Osteopathic Medicine
Westbrook College of Health Professions
Center for Pain Research (COBRE)
    Director, In Vitro Analytical Core
      Center for Cell Signaling Research
    Chair, IACUC
      Office of Research Integrity
    Location
        
            Pickus Center for Biomedical Research 205
      
  
    
      
        
            Biddeford Campus
      
  
    
  Eligible for Student Opportunities
      
  
    Credentials
Education
        
            MD
      
  
    
      
        
            Beijing Medical University
      
  
    
      
        
            1997
      
  
    
        
            PhD
      
  
    
      
        
            SUNY Albany
      
  
    
      
        
            2002
      
  
    
        
            MPH
      
  
    
      
        
            Johns Hopkins University
      
  
    
      
        
            2024
      
  
    
Post-Doctoral Training
        
            Post-Doctoral Training, Neuroimmunology
Dartmouth College (Lebanon, New Hampshire)
Post-Doctoral Training, Psychoneuroimmunology
University of Rochester (Rochester, New York)
      
  
    
Dartmouth College (Lebanon, New Hampshire)
Post-Doctoral Training, Psychoneuroimmunology
University of Rochester (Rochester, New York)
Research
Current research
- Role of Toll-like receptor pathway in HIV-associated peripheral neuropathy.
- Role of CD137L (AKA. 4-1BBL) in peripheral nerve injury-induced neuropathic pain and nerve regeneration.
- Population research related to chronic pain.
- Educational research related to interprofessional education.
Selected publications
Please view the complete list of our publications through the following link:
http://www.ncbi.nlm.nih.gov/myncbi/ling.cao.1/bibliography/46382587/public/?sort=date&direction=ascending
- L. Cao, L. Fei, T. T. Chang, and J. A. DeLeo. 2007. Further induction of IL-1beta by IL-4 in LPS-treated mixed glial cultures. Journal of Neurochemistry 102(2), 408-419.
- C. A. Hudson, G. P. Christophi, L. Cao, R. C. Gruber and P. T. Massa. 2007. Regulation of avoidant behaviors and pain by the anti-inflammatory tyrosine phosphatase SHP-1. Neuron Glia Biology 2 (4), 235-246.
- I. D. Meng and L. Cao. 2007. From migraine to chronic daily headache: the biological basis of headache transformation (Invited review). Headache 47(8), 1251-1258.
- L. Cao and J. A. DeLeo. 2008. CNS infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. European Journal of Immunology 38, 448-458 (featured “In This Issue”). (PMCID: PMC2963094)
- L. Cao, F.Y. Tanga and J. A. DeLeo. 2009. The contributing role of CD14 in Toll-Like receptor 4 dependent neuropathic pain. Neuroscience 158(2), 896-903. (PMCID: PMC2701510)
- L. Cao, C. D. Palmer, J. T. Malon and J. A. DeLeo. 2009. Critical role of microglial CD40 in the maintenance of mechanical hypersensitivityin a murine model of neuropathic pain. European Journal of Immunology 39, 3562-3569. (PMCID: PMC2810130)
- J. T. Malon, S. Maddula, H. Bell and L. Cao. 2012. Involvement of calcitonin gene-related peptide and CCL2 production in CD40-mediated behavioral hypersensitivity in a model of neuropathic pain. Neuron Glia Biology (Mar 1:1-12; published online).(PMCID: PMC4110723)
- L. Cao, M. B. Butler, L. Tan and K. S. Draleau. 2012. A murine immunodeficiency virus induced peripheral neuropathy and associated cytokine responses. Journal of Immunology 189(7), 3724-33. (PMCID: PMC3448875).
- L. Cao, H. Beaulac, and A. Eurich. 2012. Differential lumbar spinal cord responses among wild type, CD4 knockout, and CD40 knockout mice in spinal nerve L5 transection-induced neuropathic pain. Molecular pain 8(1), 88. (PMCID: PMC3545955)
- L. Cao and M. B. Butler. 2013. Involvement of microglial CD40 in murine retrovirus-induced peripheral neuropathy. Journal of Neuroimmunology 261, 37-43. (PMCID: PMC3729793)
- K. S. Draleau, S. Maddula, A. Slaiby, N. Nutile-McMenemy, J. A. DeLeo, and L. Cao. 2014. Phenotypic identification of spinal cord-infiltrating CD4+ T lymphocytes in a murine model of neuropathic pain. Journal of Pain and Relief S3:003. Doi: 10.4172/2167-0846.S3-003 (PMCID: PMC4136538)
- V. D. McLane, L. Cao, and C. L. Willis. 2014. Morphine increases hippocampal viral load and suppresses frontal lobe cytokine expression in the LP-BM5 AIDS model. Journal of Neuroimmunology 269(1), 44-51. (PMCID:PMC4026271)
- J. Malon, E. Grlickova-Duzevik, J. Vaughn, T. R. Vunk, and L. Cao. 2015. Microglial Content-Dependent Inhibitory Effects of Calcitonin Gene-Related Peptide (CGRP) on Murine Retroviral Infection of Glial Cells. Journal of Neuroimmunology 279(1), 64-70. (PMCID: PMC4325278)
- J. Malon and L. Cao. 2016. Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways. Journal of Neuroimmunology 297,68-75. (PMCID: PMC4940993)
- J. Malon and L. Cao. 2016. Preparation of primary mixed glial cultures from adult mouse spinal cord tissue. Journal of Visualized Experiments. Nov 19;(117). doi: 10.3791/54801. (PMCID: PMC5153361)
Research topics
Animal Model
      Animal Studies/ Human-animal Studies
      Behavioral Neuroscience
      COM Immunology and Infectious Disease
      COM Medical and Interprofessional Education
      COM Neuroscience and Pain